Реакция #453375

Уравнение реакции

sodium hydrogen carbonate sodium carbonate

sodium hydrogen carbonate

Trifluoroacetic acid

N-((1R)-2-(2-Fluorophenyl)-1-(methylcarbamoyl)ethyl)-N-methylcarbamic acid tert-butylester

→

(2R)-3-(2-fluorophenyl)-N-methyl-2-(methylamino)-propionamide

Выход 67.7%

Растворители

Methylene chloride

methylene chloride

Условия реакции

Обработка

1. 1
   СушкаThe organic phase was dried (magnesium sulfate)
2. 2
   Другоеevaporated in vacuo

Методика

N-((1R)-2-(2-Fluorophenyl)-1-(methylcarbamoyl)ethyl)-N-methylcarbamic acid tert-butylester (2.4 g; 7.73 mmol) was dissolved in methylene chloride. Trifluoroacetic acid (10 mL) was added and the reaction mixture was stirred for 30 min at room temperature. Methylene chloride (30 mL), an aqueous solution of sodium hydrogen carbonate/sodium carbonate (pH 9; 30 mL) and sodium hydrogen carbonate (solid) were added to the reaction mixture until pH 8. The organic phase was dried (magnesium sulfate) and evaporated in vacuo to afford 1.1 g of (2R)-3-(2-fluorophenyl)-N-methyl-2-(methylamino)-propionamide.

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