Реакция #45292

Уравнение реакции

(6-Trifluoromethylpyridin-2-yl)methanol

thionyl chloride

→

2-chloromethyl-6-trifluoromethylpyridine

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   ДругоеSolvent was removed under the reduced pressure
2. 2
   Экстракцияthe product was extracted with EtOAc
3. 3
   ДругоеPurification by flash column (5% EtOAc-Hexane)

Методика

(6-Trifluoromethylpyridin-2-yl)methanol (760 mg, 4.3 mmol) was dissolved in CH2Cl2 and thionyl chloride was added slowly at room temperature. The reaction mixture was stirred at room temperature for 4 h. Solvent was removed under the reduced pressure, the pH was adjusted to 5, and the product was extracted with EtOAc. Purification by flash column (5% EtOAc-Hexane) gave 2-chloromethyl-6-trifluoromethylpyridine (200 mg) as a white solid.

Источник