Реакция #45268

ord-be98669f9d524fc3869fd94f06b0badf

Уравнение реакции

OC1(C(F)(F)F)CCNCC1
4-(trifluoromethyl)piperidin-4-ol
ClCCBr
1-bromo-2-chloroethane
→
OC1(C(F)(F)F)CCN(CCCl)CC1
1-(2-chloroethyl)-4-(trifluoromethyl)piperidin-4-ol

Реактанты

OC1(C(F)(F)F)CCNCC1
4-(trifluoromethyl)piperidin-4-ol
ClCCBr
1-bromo-2-chloroethane

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

A solution of 4-(trifluoromethyl)piperidin-4-ol and 1-bromo-2-chloroethane are reacted using the procedure for Example OO to afford 1-(2-chloroethyl)-4-(trifluoromethyl)piperidin-4-ol.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07737283B2uspto-grants-2010_06