Реакция #452426

Уравнение реакции

2-iodopropane

2-(4-pyrazolyl)-1-ethanol

sodium carbonate

→

title compound

Выход 26.0%

2-(1-isopropyl-1H-pyrazol-4-yl)-1-ethanol

Выход 26.0%

Растворители

dimethylformamide

dimethylformamide

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was then cooled to ambient and
2. 2
   Концентрированиеthen concentrated under reduced pressure
3. 3
   ДругоеThe residue was partitioned between water and dichloromethane
4. 4
   ПромывкаThe organic phase was then washed with water
5. 5
   Сушкаwas then dried over sodium sulfate
6. 6
   КонцентрированиеThe remaining organics were concentrated under reduced pressure

Методика

To a solution of 1.0 gm (9.0 mMol) 2-(4-pyrazolyl)-1-ethanol in 36 mL dimethylformamide were added 2.38 gm (22.5 mMol) sodium carbonate followed by the dropwise addition of a solution of 0.89 mL (9.0 mMol) 2-iodopropane in 8 mL dimethylformamide. The reaction mixture was heated to 100° C. for 18 hours. The reaction mixture was then cooled to ambient and then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. The organic phase was then washed with water followed by saturated aqueous sodium chloride and was then dried over sodium sulfate. The remaining organics were concentrated under reduced pressure to give 0.36 gm (26.0%) of the title compound as a brown oil.

Источник