Реакция #44997

Уравнение реакции

Monomethyl adipate

morpholine

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

triethylamine

→

methyl 6-morpholin-4-yl-6-oxohexanoate

Выход 100.4%

Растворители

chloroform

Условия реакции

Обработка

1. 1
   Температураcooling
2. 2
   Экстракцияthe mixture is extracted with chloroform
3. 3
   ПромывкаThe organic layer is washed with 10% hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine successively
4. 4
   Сушкаdried over sodium sulfate
5. 5
   ДругоеThe solvent is removed by evaporation under reduced pressure

Методика

Monomethyl adipate (3.20 g) is dissolved in chloroform (70 ml), and thereto are added morpholine (2.61 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (5.75 g) and triethylamine (3.04 g) under ice-cooling. The mixture is then stirred at room temperature for 19 hours. Ice-water is added to the reaction solution and the mixture is extracted with chloroform. The organic layer is washed with 10% hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and saturated brine successively and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure to give methyl 6-morpholin-4-yl-6-oxohexanoate (4.63 g).

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