Реакция #44954

Уравнение реакции

Pseudomonic acid

potassium hydroxide

calcium chloride

→

Mupirocin Calcium

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Фильтрацияthe solution was filtered
2. 2
   Другоеto remove potassium chloride (0.51 g)
3. 3
   ДругоеThe ethanol was subsequently evaporated at reduced pressure
4. 4
   Другоеto give a solid, white foam
5. 5
   ДругоеThe product was dried for 12 hours at 45° C. under vacuum

Методика

Pseudomonic acid (5.00 g, 10 mmole) was dissolved in ethanol (20 ml), ethanolic solution of potassium hydroxide (0.56 g, 10 mmole potassium hydroxide and 10 ml ethanol) and ethanolic solution of calcium chloride (0.56 g, 5.0 mmole calcium chloride and 10 ml ethanol) were added to the mixture. The mixture was stirred for 1 hour and the solution was filtered to remove potassium chloride (0.51 g). The ethanol was subsequently evaporated at reduced pressure to give a solid, white foam. The product was dried for 12 hours at 45° C. under vacuum. The product had a mass of 4.38 grams. Assay: 99.1%, water: 2.36% [total impurity: 2.44%, highest impurity: 1.10% different method than the assay].

Источник