Реакция #44944

ord-4e0ef7ba04fb4e29ba37bc91f2b6c1e1

Уравнение реакции

$C/C(=C\C(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O$

Pseudomonic acid

Calcium oxide

→

$C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.O.O.[Ca+2]$

Mupirocin calcium dihydrate

Выход 131.3%

Реактанты

$C/C(=C\C(=O)OCCCCCCCCC(=O)O)C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O$

Pseudomonic acid

Calcium oxide

Реагенты

Нет

Растворители

water

Условия реакции

Температура

5°CELSIUS

Подробные условия

See reaction.notes.procedure_details.

Обработка

1
Фильтрацияfiltered
2
workup.WAITAfter standing for 15 h
3
Фильтрацияthe crystalline product was filtered
4
Промывкаwashed with cooled water (10 ml)
5
Другоеdried in an air
6
Другоеat room temperature

Методика

Pseudomonic acid (10 g) was suspended in water (26 ml). Calcium oxide (0.58 g) was added to the suspension. The mixture was stirred for one hour, and filtered. The mixture was cooled to 5° C. After standing for 15 h, the crystalline product was filtered and washed with cooled water (10 ml) and dried in an air circulated oven at room temperature. Mupirocin calcium dihydrate (9.4 g, 87%) was obtained.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07737177B2uspto-grants-2010_06