Реакция #44924

Уравнение реакции

selenium dioxide

water

2′,5′-dimethoxyacetophenone

→

(2,5-dimethoxyphenyl)-2-oxoacetaldehyde

Растворители

dioxane

Условия реакции

Обработка

1. 1
   Температураthe mixture is refluxed for 16 hours
2. 2
   ДругоеThe solvents are evaporated off (orange-coloured oil; 6 g)
3. 3
   Другоеthe product obtained
4. 4
   Другоеis purified by flash chromatography (dichloromethane) (3.1 g of yellow oil; 53%)

Методика

A mixture of 3.66 g (33 mmol) of selenium dioxide, 1 ml of water and 25 ml of dioxane is heated to 60° C. 5.4 g (30 mmol) of 2′,5′-dimethoxyacetophenone are added and the mixture is refluxed for 16 hours. The solvents are evaporated off (orange-coloured oil; 6 g) and the product obtained is purified by flash chromatography (dichloromethane) (3.1 g of yellow oil; 53%).

Источник