Реакция #44844

Уравнение реакции

4-hydroxyindole

diethyl bromomalonate

potassium carbonate

→

7

Выход 13.0%

diethyl 2-bromo-2-(indol-4-yloxy)malonate

Выход 13.0%

8

Выход 34.0%

diethyl 2-(indol-4-yloxy)malonate

Выход 34.0%

Растворители

acetone

acetone

Условия реакции

Методика

A solution of 4-hydroxyindole (266 mg, 2 mmol) in acetone (20 mL) was cooled to 0° C. under nitrogen and anhydrous potassium carbonate (414 mg, 3 mmol) was added. A solution of freshly distilled pure diethyl bromomalonate (574 mg, 2.4 mmol) in acetone (20 mL) was added dropwise and the mixture was stirred at room temperature overnight. Work up and flash chromatography as above afforded 7 (101 mg, 13%) and 8 (199 mg, 34%).

Источник