Реакция #44775

Уравнение реакции

8-azabicyclo[3.2.1]octan-3-one hydrochloride salt

methyl 4-(bromomethyl)benzoate

potassium carbonate

→

methyl 4-[(3-oxo-8-azabicyclo[3.2.1]oct-8-yl)methyl]-benzoate

Выход 75.5%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Фильтрацияthe reaction was filtered
3. 3
   КонцентрированиеThe filtrate was concentrated
4. 4
   ДругоеPurification by chromatography on silica gel

Методика

A slurry of 8-azabicyclo[3.2.1]octan-3-one hydrochloride salt (0.52 g, 3.2 mmol) and methyl 4-(bromomethyl)benzoate (0.75 g, 3.3 mmol) in 30 mL of acetonitrile was stirred as solid potassium carbonate (1.9 g, 13.6 mmol) was added. After 4 days, the reaction was filtered. The filtrate was concentrated. Purification by chromatography on silica gel using hexane gave 0.66 g of methyl 4-[(3-oxo-8-azabicyclo[3.2.1]oct-8-yl)methyl]-benzoate.

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