Реакция #44735

Уравнение реакции

ethyl acetate

6-chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]pyrimidine-2,4-diamine

6-Chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine

3-[(2,4-dimethoxybenzyl)amino]propan-1-ol

TFA

→

3-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]propan-1-ol

Растворители

DCM

1-butanol

N-ethyl-diisopropylamine

Условия реакции

Обработка

1. 1
   ДругоеVolatile components are removed under reduced pressure
2. 2
   Другоеthe residue is purified by preparative HPLC
3. 3
   ДругоеThe substrate obtained
4. 4
   Экстракцияextracted with sat. sodium carbonate solution
5. 5
   СушкаThe organic phase is dried over sodium sulfate
6. 6
   Другоеthe solvent is removed under reduced pressure
7. 7
   ДругоеThe residue is purified by preparative HPLC

Методика

78 mg (0.21 mmol) of 6-chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]pyrimidine-2,4-diamine (from example 60), 190 mg (0.84 mmol) of 3-[(2,4-dimethoxybenzyl)amino]propan-1-ol in 1 ml of 1-butanol and 0.37 ml of N-ethyl-diisopropylamine are, in a closed pressure vessel, heated at 130° C. overnight. Volatile components are removed under reduced pressure, and the residue is purified by preparative HPLC. The substrate obtained is taken up in 2 ml of DCM, and 0.5 ml of TFA is added. The mixture is stirred at RT for 20 min and then poured into ethyl acetate and extracted with sat. sodium carbonate solution. The organic phase is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC.

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