Реакция #447163

Уравнение реакции

p-butylbenzoyl chloride

6-amino-1-hexanol

triethylamine

→

desired product

Выход 85.4%

4-Butyl-N-(6-hydroxyhexyl)benzamide

Выход 85.4%

Растворители

dichloromethane

dichloromethane

Условия реакции

Обработка

1. 1
   ПромывкаThen the mixture was washed in succession with water, saturated sodium carbonate, water, and finally brine
2. 2
   СушкаThe organic layer was dried over anhydrous sodium sulfate
3. 3
   Другоеevaporated in vacuo
4. 4
   ДругоеThe residue was triturated
5. 5
   Фильтрацияfiltered
6. 6
   Промывкаrinsed with cold hexane

Методика

To a stirred solution of 23.5 g of 6-amino-1-hexanol and 30 g of triethylamine in 200 ml of dichloromethane, cooled in an ice bath, was added dropwise a solution of 43.3 g of p-butylbenzoyl chloride in 100 ml of dichloromethane. The mixture was allowed to stir at room temperature for 16 hours. Then the mixture was washed in succession with water, saturated sodium carbonate, water, and finally brine. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was triturated, filtered, and rinsed with cold hexane and gave 47.5 g of the desired product in 61% yield as a beige solid, m.p. 80°-81° C.

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