Реакция #447049

Уравнение реакции

5,5-Diphenyl-3-hydroxymethyl-2,4-imidazolidinedione

2-bromopropionyl chloride

→

3-(2'-Bromopropionyl)oxymethyl-5,5-diphenyl-2,4-imidazolidinedione

Растворители

ethyl ether

Условия реакции

Обработка

1. 1
   Температураby heating for 30 minutes on a 100°-110° C. oil bath
2. 2
   ТемператураThe reaction mixture was cooled
3. 3
   Экстракцияthe resultant solution was extracted with aqueous potassium carbonate
4. 4
   Другоеdried
5. 5
   Другоеcrystallized
6. 6
   ДругоеThe product was obtained as a solid white substance (1 g, 34%), m.p. 112°-115° C

Методика

5,5-Diphenyl-3-hydroxymethyl-2,4-imidazolidinedione (2 g, 0.0071 mol) was dissolved in 2-bromopropionyl chloride (8.5 g, 5 mL, 0.05 mol) by heating for 30 minutes on a 100°-110° C. oil bath. The reaction mixture was cooled, 20 mL of ethyl ether were added, and the resultant solution was extracted with aqueous potassium carbonate, dried and then crystallized. The product was obtained as a solid white substance (1 g, 34%), m.p. 112°-115° C. Anal. calc. for C19H17N2O4Br: C, 54.69; H, 4.11; N, 6.72; Br, 19.15. Found: C, 54.77; H, 4.15; N, 6.69; Br, 19.25. The product had the formula: ##STR77##

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