Реакция #44702

Уравнение реакции

N-[3-fluoro-4-({1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)phenyl]-4-methylphenylsulfonamide

sodium hydroxide

→

[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]amine

Растворители

sulfuric acid

Условия реакции

Обработка

1. 1
   ТемператураWith ice-cooling
2. 2
   Экстракцияthe mixture is extracted three times with ethyl acetate
3. 3
   СушкаThe organic phase is dried over anhydrous magnesium sulfate
4. 4
   Концентрированиеconcentrated

Методика

50 mg (0.09 mmol) of N-[3-fluoro-4-({1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yl}oxy)phenyl]-4-methylphenylsulfonamide (from example XLV) are dissolved in 1.00 ml of sulfuric acid (95%) and stirred at RT overnight. With ice-cooling, the reaction solution is neutralized with 20% strength aqueous sodium hydroxide solution, and the mixture is extracted three times with ethyl acetate. The organic phase is dried over anhydrous magnesium sulfate and concentrated.

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