Реакция #446464

Уравнение реакции

adamantyl urea

ethyl 2-chloro-4,4,4-trifluoroacetoacetate

→

white solid

Выход 39.1%

Ethyl 2-(1-adamantanylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate

Выход 39.1%

Условия реакции

Обработка

1. 1
   ДругоеThe product was separated
2. 2
   Другоеrecrystallized from methylcyclohexane

Методика

By the procedure of Example 4, 11.6 g (60 mmol) of adamantyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 24 hours. The product was separated and then recrystallized from methylcyclohexane to yield 7.0 g of a white solid product (m.p.=109°-111° C.) identified in Table I.

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