Реакция #44597

Уравнение реакции

3-{4-{1-[(S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-(3E)-ylidenemethyl}-2-methoxyphenyl}-5-methyl-1-(phosphonooxymethyl)-3H-imidazol-1-ium trifluoroacetate

water

→

title compound

Выход 90.7%

1-{4-{(E)-1-{[(S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-3-ylidene}methyl}-2-methoxyphenyl}-4-methyl-1H-imidazol-3-iomethyl monohydrogenphosphate

Выход 90.7%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   КонцентрированиеThe objective fraction was concentrated

Методика

An aqueous solution (4 mL) of 3-{4-{1-[(S)-1-(4-fluorophenyl)ethyl]-2-oxopiperidin-(3E)-ylidenemethyl}-2-methoxyphenyl}-5-methyl-1-(phosphonooxymethyl)-3H-imidazol-1-ium trifluoroacetate (150 mg) obtained in Example 1 was subjected to reversed phase C18 silica gel column chromatography (developing solvent: 100% water to 35% acetonitrile aqueous solution). The objective fraction was concentrated and then lyophilized to give 112 mg of the title compound. The physical property values of this compound were as follows:

Источник