Реакция #44525

Уравнение реакции

4-chloro-2-methylsulfanylpyrimidine

ammonia

→

2-(methylsulfanyl)-4-pyrimidinamine

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураcooled
2. 2
   Концентрированиеconcentrated
3. 3
   workup.ADDITIONtreated with water
4. 4
   Экстракцияextracted with ethyl acetate
5. 5
   ПромывкаThe extract was washed with brine
6. 6
   Сушкаdried over anhydrous sodium sulfate
7. 7
   Концентрированиеconcentrated
8. 8
   ДругоеThe concentrate was triturated with ethyl ether
9. 9
   Фильтрацияfiltered

Методика

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

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