Реакция #44504

Уравнение реакции

product

Cyclohept-4-enol

imidazole

Tert-butyl-chlorodiphenylsilane

→

title compound

tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane

Растворители

N,N-dimethylformamide

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was partitioned between ethyl acetate and water
2. 2
   ПромывкаThe organic layer was washed with brine (25 mL)
3. 3
   Сушкаdried with MgSO4
4. 4
   Фильтрацияfiltered
5. 5
   Другоеsolvent evaporated in vacuo
6. 6
   ДругоеThe crude product was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 90:10)

Методика

A solution of the product of Example 8B (1.57 g, 14.05 mmoles), imidazole (1.43 g, 21.08 mmoles), and Tert-butyl-chlorodiphenylsilane (4.76 gm, 17.4 mmoles) in N,N-dimethylformamide (10 mL) was stirred for five hours at 23° C. The reaction was partitioned between ethyl acetate and water. The organic layer was washed with brine (25 mL), dried with MgSO4, filtered, and solvent evaporated in vacuo. The crude product was purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 90:10) to provide the title compound as an oil.

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