Реакция #44496

Уравнение реакции

Tetrabutyl ammonium fluoride

product

4-(tert-Butyl-diphenyl-silanyloxymethyl)-1-(5-hydroxy-cyclooctyl)-3,3-dimethyl-pyrrolidin-2-one

→

titled product

1-(5-Hydroxy-cyclooctyl)-4-hydroxymethyl-3 3-dimethyl-pyrrolidin-2-one

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Другоеpartitioned with ethyl acetate and water
2. 2
   ПромывкаThe organic phase was washed with brine
3. 3
   Сушкаdried (MgSO4)
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated
6. 6
   ДругоеThe residue was purified over silica gel using 20-100% ethyl acetate in hexanes

Методика

Tetrabutyl ammonium fluoride (0.76 mL, 1 M in tetrahydrofuran, 0.76 mmol) was added to a stirred solution of the product of Example 5J (0.30 g, 0.60 mmol) in tetrahydrofuran (5 mL) at room temperature. The resulting solution was stirred for two hours and then partitioned with ethyl acetate and water. The organic phase was washed with brine, dried (MgSO4), filtered, and evaporated. The residue was purified over silica gel using 20-100% ethyl acetate in hexanes to give the titled product as a white solid.

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