Реакция #44484

ord-272aeb37cfe24c39bb51f81365c79ccf

Уравнение реакции

CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
solution
CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one
→
CC1(C)C(=O)N(C2CCCCCC2)CC1CO
title compound
CC1(C)C(=O)N(C2CCCCCC2)CC1CO
1-Cycloheptyl-4-hydroxymethyl-3,3-dimethyl-pyrrolidin-2-one

Реактанты

CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
solution
CC(C)(C)[SiH2]OC(C)(C)C1CN(C2CCCCCC2)C(=O)C1(C)C
4-(tert-Butyl-dimethyl-silanyloxymethyl)-1-cycloheptyl-3,3-dimethyl-pyrrolidin-2-one

Реагенты

Cl
HCl

Растворители

CO
methanol

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Обработка

  1. 1
    ДругоеThe solvent was evaporated in vacuo

Методика

Two drops of 12M HCl was added to a solution of Example 1D (75 mg, 0.21 mmoles) in methanol (1.25 mL) and stirred for one hour at room temperature. The solvent was evaporated in vacuo to provide the title compound as a colorless oil.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07737137B2uspto-grants-2010_06