Реакция #44423

Уравнение реакции

HCl

sodium

Diethyl malonate

n-propylurea

sodium

→

1-Propylbarbituric acid

Растворители

water

ethanol

Условия реакции

Обработка

1. 1
   Температураunder reflux for 5 h
2. 2
   Фильтрацияthe mixture is filtered
3. 3
   Концентрированиеthe filtrate is concentrated in vacuo
4. 4
   workup.ADDITIONEthanol is added to the residue
5. 5
   workup.STIRRINGthe mixture is stirred
6. 6
   ФильтрацияThe solid is filtered off with suction
7. 7
   Другоеdried

Методика

Metallic sodium (2.6 g, 113 mmol) is added to ethanol (60 ml). The mixture is stirred until the sodium has completely finished reacting. Diethyl malonate (116 ml, 105 mmol) and n-propylurea (10 g, 98 mmol) are then added and the mixture is stirred under reflux for 5 h. After conc. HCl (5 ml) and hot water (45 ml) have been added, the mixture is filtered and the filtrate is concentrated in vacuo. Ethanol is added to the residue and the mixture is stirred. The solid is filtered off with suction and dried.

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