Реакция #4438

Уравнение реакции

chloroform

4-(4-aminophenylamino)-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

methanesulfonyl chloride

triethylamine

→

6-(3,4-dimethoxyphenyl)-4-(4-mesylaminophenylamino)-2-methylpyrimidine

Растворители

1,2-dichloroethane

Условия реакции

Обработка

1. 1
   Температураthe mixture was refluxed for 3 hours
2. 2
   ТемператураAfter cooled
3. 3
   Промывкаwashed with water
4. 4
   СушкаThe solution was dried over magnesium sulfate
5. 5
   Другоеevaporated
6. 6
   Другоеchromatographed on silica gel eluting with chloroform

Методика

To a solution of 4-(4-aminophenylamino)-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.0 g) in 1,2-dichloroethane (20 ml) were added methanesulfonyl chloride (0.28 ml) and triethylamine (0.83 ml) and the mixture was refluxed for 3 hours. After cooled, chloroform (50 ml) was added thereto, and washed with water. The solution was dried over magnesium sulfate, evaporated, and chromatographed on silica gel eluting with chloroform to give 6-(3,4-dimethoxyphenyl)-4-(4-mesylaminophenylamino)-2-methylpyrimidine (0.45 g).

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