Реакция #4436

Уравнение реакции

6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine

triethylamine

2,4-dichloro-5-sulfamoylbenzoyl chloride

→

4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

Выход 71.5%

Растворители

chloroform

Условия реакции

Обработка

1. 1
   ПромывкаThe reaction mixture was washed with water
2. 2
   Сушкаdried over magnesium sulfate
3. 3
   Другоеevaporated
4. 4
   ДругоеThe obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v)

Методика

To a solution of 6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine (0.8 g) in chloroform (10 ml) were added triethylamine (0.39 ml) and 2,4-dichloro-5-sulfamoylbenzoyl chloride (0.74 g), and the mixture was stirred at ambient temperature for 20 hours. The reaction mixture was washed with water, dried over magnesium sulfate, and evaporated. The obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v), to give 4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.03 g).

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