Реакция #44351

Уравнение реакции

product

1,1-dimethylethyl [[3′,5-dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetate

→

title compound

[[3′,5-Dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetic acid

Растворители

TFA

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed in vacuo
2. 2
   Другоеthe mixture was azeotroped with toluene
3. 3
   Другоеpurified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent)

Методика

A solution of the more polar product from Example 2 step d) (35 mg) in TFA (2 ml) was stirred for 24 h. The solvent was removed in vacuo, the mixture was azeotroped with toluene and purified by chromatography (silica, CH2Cl2-MeOH—AcOH as eluent) to give the title compound (22 mg) as a white solid.

Источник