Реакция #442165

Уравнение реакции

1-(3-chloropropyl)-1H-benzimidazole

1-[(2-chlorophenyl)phenylmethyl]piperazine acetate

sodium carbonate

potassium iodide

→

1-[3-{4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl}propyl]-1H-benzimidazole trihydrochloride dihydrate

Растворители

4-methyl-2-pentanone

water

water

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture is cooled
2. 2
   Другоеthe layers are separated
3. 3
   ДругоеThe organic phase is dried
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated
6. 6
   ФильтрацияThe salt is filtered off
7. 7
   Другоеcrystallized from 2-propanol

Методика

A mixture of 4.9 parts of 1-(3-chloropropyl)-1H-benzimidazole, 7 parts of 1-[(2-chlorophenyl)phenylmethyl]piperazine acetate, 10.6 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 20 hours with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is converted into the hydrochloride salt in 2-propanol and 2,2'-oxybispropane. The salt is filtered off and crystallized from 2-propanol, yielding 1-[3-{4-[(2-chlorophenyl)phenylmethyl]-1-piperazinyl}propyl]-1H-benzimidazole trihydrochloride dihydrate; mp. 182.9° C.

Источник