Реакция #442163

Уравнение реакции

1-(3-chloropropyl)-1H-benzimidazole

1-[bis(4-fluorophenyl)methyl]piperazine

sodium carbonate

potassium iodide

→

1-[3-{4-[bis(4-fluorophenyl)methyl]-1-piperazinyl}propyl]-1H-benzimidazole hydrate

Растворители

4-methyl-2-pentanone

water

water

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture is cooled
2. 2
   Другоеthe layers are separated
3. 3
   ДругоеThe organic phase is dried
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated
6. 6
   ДругоеThe residue is crystallized from a mixture of 4-methyl-2-pentanone and 2,2'-oxybispropane
7. 7
   ФильтрацияThe product is filtered off
8. 8
   Другоеdried

Методика

A mixture of 4.9 parts of 1-(3-chloropropyl)-1H-benzimidazole, 5.76 parts of 1-[bis(4-fluorophenyl)methyl]piperazine, 5.3 parts of sodium carbonate, 0.1 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 20 hours with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is crystallized from a mixture of 4-methyl-2-pentanone and 2,2'-oxybispropane. The product is filtered off and dried, yielding 1-[3-{4-[bis(4-fluorophenyl)methyl]-1-piperazinyl}propyl]-1H-benzimidazole hydrate; mp. 108.4° C.

Источник