Реакция #44153

Уравнение реакции

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

Растворители

DCM

Условия реакции

Обработка

1. 1
   Другоеpartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   ПромывкаThe organic layer was washed with water
3. 3
   Другоеdried
4. 4
   Концентрированиеconcentrated in vacuo
5. 5
   ДругоеThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

Методика

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

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