Реакция #43994

Уравнение реакции

1,4-Diethoxy-2,3-naphthalenedicarboxylic anhydride

ethyl (4-aminophenyl)acetate

water

→

ethyl[4-(4,9-diethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetate

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   ФильтрацияThe white solid was filtered
2. 2
   Промывкаwashed with water
3. 3
   workup.DISSOLUTIONdissolved in dichloromethane (800 ml)
4. 4
   ПромывкаThe solution was washed with water, brine
5. 5
   Сушкаdried (MgSO4)
6. 6
   Другоеthe solvent evaporated under vacuum

Методика

1,4-Diethoxy-2,3-naphthalenedicarboxylic anhydride (23.3 g, 81.5 mmol) and ethyl (4-aminophenyl)acetate (14.8 g, 82 mmol) were refluxed under nitrogen in acetic acid (160 ml) overnight. The mixture was cooled to room temperature and poured into water (1 L). The white solid was filtered, washed with water and dissolved in dichloromethane (800 ml). The solution was washed with water, brine and dried (MgSO4) and the solvent evaporated under vacuum to give ethyl[4-(4,9-diethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetate as an off-white solid, 33 g, 96%.

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