Реакция #43938

Уравнение реакции

4-bromo-3,5-dimethylphenol

3-(methylthio)-1-propanol

tributylphosphine

1,1′-(azodicarbonyl)dipiperidine

→

title compound

Выход 87.0%

2-bromo-1,3-dimethyl-5-[3-(methylthio)propoxy]benzene

Выход 87.0%

Растворители

Hexane

toluene

Условия реакции

Обработка

1. 1
   Фильтрацияthe insoluble substance was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure
3. 3
   ДругоеThe residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-25:75)

Методика

To a solution of 4-bromo-3,5-dimethylphenol (4.02 g, 20.0 mmol), 3-(methylthio)-1-propanol (2.12 g, 20.0 mmol) and tributylphosphine (7.97 mL, 32.0 mmol) in toluene (320 mL) was added 1,1′-(azodicarbonyl)dipiperidine (8.07 g, 32.0 mmol), and the mixture was stirred at room temperature for 18 hr under nitrogen atmosphere. Hexane (160 mL) was added to the reaction mixture, the insoluble substance was filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=0:100-25:75) to give the title compound (5.03 g, yield 87%) as a pale-yellow oil.

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