Реакция #43926

Уравнение реакции

4-bromo-3,5-dimethylphenol

acetic anhydride

→

title compound

Выход 128.9%

4-bromo-3,5-dimethylphenyl acetate

Выход 128.9%

Растворители

hydrochloric acid

pyridine

Условия реакции

Обработка

1. 1
   Температураcooled
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   ПромывкаThe extract was washed with saturated brine
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   Концентрированиеconcentrated under reduced pressure

Методика

To a solution of 4-bromo-3,5-dimethylphenol (10.1 g, 50.0 mmol) in pyridine (13 mL) was added acetic anhydride (7.66 g, 38.6 mmol), and the mixture was stirred at 50° C. for 30 min. The reaction mixture was ice-cooled, diluted with 0.5 M hydrochloric acid, and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (12.1 g, yield 99%) as a yellow oil.

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