Реакция #43864

Уравнение реакции

Cyclohexanecarbonyl chloride

(5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

DIEA

→

subtitle compound

[5-(Benzyl-cyclohexanecarbonyl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

Растворители

HCl

CH2Cl2

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered through an Extrelut column
2. 2
   ПромывкаThe Extrelut column was washed with CH2Cl2
3. 3
   Концентрированиеthe filtrate was concentrated

Методика

Cyclohexanecarbonyl chloride (48 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C30H39N3O3+H: 490, observed: 490.

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