Реакция #43828

Уравнение реакции

2-Trifluoromethylbenzyl bromide

K2CO3

[5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

→

{5-[(2-Trifluoromethyl-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

Растворители

EtOAc

H2O

CH3CN

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered through an Extrelut column
2. 2
   ПромывкаThe column was washed with EtOAc
3. 3
   Концентрированиеthe filtrate was concentrated
4. 4
   ДругоеThe crude product was carried onto the next reaction without any further purification or characterization

Методика

2-Trifluoromethylbenzyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

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