Реакция #4376

Уравнение реакции

3-methoxybenzeneacetic acid

iodine monochloride

water

→

2-iodo-5-methoxybenzeneacetic acid

Выход 65.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Другоеthe solid collected
2. 2
   ДругоеIt was recrystallized from toluene

Методика

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

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