Реакция #43639

Уравнение реакции

2,3-dihydro-1-benzofuran-5-carbaldehyde

sodium acetate

bromine

→

desired compound

Выход 91.3%

7-bromo-2,3-dihydro-1-benzofuran-5-carbaldehyde

Выход 91.3%

Растворители

acetic acid

sodium thiosulfate

Условия реакции

Обработка

1. 1
   Промывкаwashed with a saturated aqueous solution of sodium bicarbonate
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   Сушкаdried over sodium sulfate
4. 4
   Другоеdried in vacuo

Методика

To a solution of 2,3-dihydro-1-benzofuran-5-carbaldehyde (1.0 g, 6.75 mmol) in glacial acetic acid (8 mL) was added sodium acetate (664 mg, 8.1 mmol) and bromine (0.7 ml, 13.5 mmol) at 10° C. slowly. The reaction was stirred for 2 hours at ambient temperature. The reaction was diluted with a saturated aqueous solution of sodium thiosulfate (10 mL), washed with a saturated aqueous solution of sodium bicarbonate, and then extracted with ethyl acetate. Organics were combined, dried over sodium sulfate and dried in vacuo to give the desired compound (1.4 g, 91%).

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