Реакция #436147

Уравнение реакции

2-Chloroisonicotinonitrile

dipropylamine

→

title compound

2-(Dipropylamino)isonicotinonitrile

Условия реакции

Обработка

1. 1
   ДругоеThe mixture was removed
2. 2
   Температураfrom heat
3. 3
   Температураcooled to room temperature
4. 4
   ДругоеThe dipropylamine was removed under reduced pressure
5. 5
   Другоеthe residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent

Методика

2-Chloroisonicotinonitrile (1.0 g) and dipropylamine (10 mL) were placed in a sealed heavy wall tube and heated to 100° C. for 18 h. The mixture was removed from heat and cooled to room temperature. The dipropylamine was removed under reduced pressure and the residue chromatographed on silica gel using 2% ethyl acetate in hexanes as eluent to give 1.06 g of the title compound: MS (ESI+) for C12H17N3 m/z 204.1 (M+H)+.

Источник