Реакция #43586

Уравнение реакции

3-fluoro-4,5-dihydroxybenzaldehyde

potassium carbonate

1,2-dibromoethane

→

desired compound

Выход 95.4%

8-fluoro-2,3-dihydro-1,4-benzodioxin-6-carboxaldehyde

Выход 95.4%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Другоеwas removed under reduced pressure
2. 2
   workup.ADDITIONThe reaction mixture was then treated with dichloromethane and water
3. 3
   ЭкстракцияThe aqueous phase was extracted twice with dichloromethane
4. 4
   Другоеthe combined organic phases were dried
5. 5
   Другоеthe solvent was removed under reduced pressure

Методика

To a solution of 3-fluoro-4,5-dihydroxybenzaldehyde (0.66 g, 4.2 mmol) in DMF (30 ml) was added potassium carbonate (1.15 g, 8.3 mmol) and 1,2-dibromoethane (0.72 ml, 8.3 mmol) and the resultant mixture was heated to 80° C. for 18 h before the solvent was removed under reduced pressure. The reaction mixture was then treated with dichloromethane and water. The aqueous phase was extracted twice with dichloromethane and the combined organic phases were dried and the solvent was removed under reduced pressure to give the desired compound as a cream solid (0.73 g, 95%).

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