Реакция #43464

Уравнение реакции

compound 1G

2-Hydroxybicyclo[3.2.0]heptan-6-one

Et3N

benzoyl chloride

→

title compound

Выход 86.3%

6-Oxobicyclo[3.2.0]heptan-2-yl benzoate

Выход 86.3%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   Другоеquenched with water
2. 2
   ЭкстракцияThe product was extracted with CH2Cl2
3. 3
   Промывкаthe organics were washed with saturated aqueous NaHCO3
4. 4
   Сушкаdried over Na2SO4
5. 5
   Концентрированиеconcentrated
6. 6
   ДругоеPurification by silica gel chromatography (5% EtOAc in hexanes)

Методика

To a stirred solution of compound 1G (1.9 g, 15.1 mmol) in CH2Cl2 (10 mL) at 0° C. under nitrogen were added Et3N (3.1 mL, 22.2 mmol) and benzoyl chloride (2.33 g, 16.6 mmol). The reaction was stirred at 0° C. for 60 min and RT for 30 min, then quenched with water. The product was extracted with CH2Cl2, the organics were washed with saturated aqueous NaHCO3, dried over Na2SO4, and concentrated. Purification by silica gel chromatography (5% EtOAc in hexanes) provide the title compound (3 g).

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