Реакция #43446

Уравнение реакции

bromomaleic anhydride

Hydrazine sulphate salt

bromomaleic anhydride

hydrazine sulphate

→

4-bromo-1,2-dihydro-3,6-pyridazinedione

Выход 151.0%

Растворители

water

water

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураto reflux
3. 3
   ТемператураThe mixture was heated
4. 4
   Температураat reflux for 4 hours
5. 5
   ФильтрацияThe precipitates were collected by filtration
6. 6
   Промывкаwashed with water and acetone
7. 7
   Другоеdried as a combined batch in vacuo

Методика

Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).

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