Реакция #433597

ord-417509d1b40c4e22819fd3234a86a41e

Уравнение реакции

C=CC(=O)Cl
Acryloyl chloride
Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline
→
C=CC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
final product
C=CC(=O)Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
N-{4-[(3,4-dichloro-6-fluorophenyl)amino]quinazoline-6-yl}acrylamide

Реактанты

C=CC(=O)Cl
Acryloyl chloride
Nc1ccc2ncnc(Nc3cc(Cl)c(Cl)cc3F)c2c1
4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline

Реагенты

Нет

Растворители

C1CCOC1
THF

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

Acryloyl chloride was reacted with 4-[(3,4-dichloro-6-fluorophenyl)amino]-6-aminoquinazoline in THF, at 0° C. The final product was obtained in quantitative yield.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07172749B2uspto-grants-2007_02