Реакция #43330

Уравнение реакции

2,5-dichloropyridine

potassium vinyltrifluoroborate

triethylamine

ethanol

→

title compound

Выход 69.0%

5-chloro-2-vinylpyridine

Выход 69.0%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Температураunder reflux
2. 2
   Промывкаby washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine
3. 3
   Сушкаdrying over anhydrous sodium sulfate
4. 4
   КонцентрированиеConcentrating the solvent under reduced pressure
5. 5
   workup.DISTILLATIONthe resulting residue was distilled under reduced pressure (63° C., 8 mmHg)

Методика

A mixture of 2,5-dichloropyridine (10.0 g), potassium vinyltrifluoroborate (10.86 g), dichloromethane complex (2.5 g) of dichloro-1,1′-bis(diphenylphosphino)-ferrocene palladium (II), triethylamine (14.13 mL) and ethanol (150 mL) was stirred overnight under reflux. After cooling the system to room temperature, ethyl acetate was added, followed by washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine and drying over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was distilled under reduced pressure (63° C., 8 mmHg) to provide the title compound (6.50 g, 69%).

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