Реакция #43322

Уравнение реакции

Potassium carbonate

sodium chlorodifluoroacetate

DMF

2-bromo-5-hydroxypyridine

→

title compound

Выход 43.0%

2-bromo-5-difluoromethoxypyridine

Выход 43.0%

Растворители

ether

Условия реакции

Обработка

1. 1
   ДругоеThe reaction liquid
2. 2
   Температураwas cooled to room temperature
3. 3
   Промывкаwashed with water
4. 4
   Сушкаdried over anhydrous magnesium sulfate
5. 5
   КонцентрированиеConcentrating the solvent under reduced pressure
6. 6
   Другоеthe resulting residue was purified on silica gel column chromatography (C-300; hexane:ethyl acetate=100:1-100:2)

Методика

Potassium carbonate (2.4 g, 17.3 mmols) and sodium chlorodifluoroacetate (4.2 g, 27.5 mmols) were added to a DMF (20 mL) solution of 2-bromo-5-hydroxypyridine (2.4 g, 13.8 mmols) and stirred overnight at 80° C. The reaction liquid was cooled to room temperature, added ether, washed with water and dried over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300; hexane:ethyl acetate=100:1-100:2) to provide the title compound (1.32 g, 43%).

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