Реакция #43311

Уравнение реакции

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one

2-(dimethylamino)ethanol

triphenylphosphine

diethyl azodicarboxylate

→

title compound

Выход 66.6%

4-benzyloxy-1-{4-[2-(dimethylamino)ethoxy]phenyl}-1H-pyridin-2-one

Выход 66.6%

Растворители

THF

Условия реакции

Обработка

1. 1
   КонцентрированиеConcentrating
2. 2
   Другоеthe reaction liquid under reduced pressure
3. 3
   Другоеthe resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10)

Методика

4-Benzyloxy-1-(4-hydroxyphenyl)-1H-pyridin-2-one (150 mg, 0.511 mmol), 2-(dimethylamino)ethanol (0.057 mL, 0.562 mmol), triphenylphosphine (269 mg, 1.02 mmols) and diethyl azodicarboxylate (0.163 mL, 1.02 mmols) were stirred overnight in THF (4 mL). Concentrating the reaction liquid under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300, methanol: chloroform=1:20-1:10) to provide the title compound (124 mg, 60%).

Источник