Реакция #4331

Уравнение реакции

acetic acid

sodium nitrite

2,5-difluoro-N-benzenesulphonylaniline

nitric acid

→

2,5-difluoro-4-nitro-N-benzenesulphonylaniline

Растворители

water

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONare added
2. 2
   ТемператураAfter cooling it
3. 3
   ДругоеThe expected product precipitates
4. 4
   ФильтрацияAfter being filtered off
5. 5
   Промывкаwashed
6. 6
   Другоеis recrystallized from 250 ml of acetic acid

Методика

To 310 ml of acetic acid diluted with 160 ml of water are added: 1.5 g of sodium nitrite, 0.16 mole (42 g) of 2,5-difluoro-N-benzenesulphonylaniline prepared in the previous stage and 0.94 mole (39 ml) of nitric acid (d=1.52). The reaction mixture is heated to 96° C. for 1 hour. After cooling it is poured onto 1 kg of ice and water. The expected product precipitates. After being filtered off and washed to neutrality it is recrystallized from 250 ml of acetic acid; it melts at 176° C.

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