Реакция #4305

Уравнение реакции

2-chloroethyl phenyl sulfone

benzylamine

triethylamine

→

N-[2-(Phenylsulfonyl)ethyl]benzenemethanamine hydrochloride

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed in vacuo
2. 2
   Другоеthe residue was partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   СушкаThe methylene chloride solution was dried over magnesium sulfate
4. 4
   workup.ADDITIONMethanol was added
5. 5
   ДругоеA white precipitate was collected
6. 6
   Другоеto give 81.30 g (74.5%) of white, crystalline solid, m.p. 211°-213° C.

Методика

A mixture of 71.90 g (0.352 mole) of 2-chloroethyl phenyl sulfone, 37.45 g (0.350 mole) of benzylamine and 60 ml of triethylamine in 800 ml of acetonitrile was stirred at room temperature for ≈64 hr. The solvent was removed in vacuo and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution was dried over magnesium sulfate, and the volume was reduced in vacuo to 300 ml. Methanol was added followed by an excess of ethereal hydrogen chloride. A white precipitate was collected to give 81.30 g (74.5%) of white, crystalline solid, m.p. 211°-213° C.

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