Реакция #4300

Уравнение реакции

ether

2-chloroethylphenylsulfone

phenethylamine

triethylamine

→

white crystalline solid

Выход 89.1%

N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate

Выход 89.1%

Растворители

methanol

hydrogen chloride

acetonitrile

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed in vacuo
2. 2
   Другоеthe residue was partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   СушкаThe methylene chloride solution was dried over magnesium sulfate
4. 4
   Другоеthe solvent was removed in vacuo
5. 5
   Другоеto give an oil
6. 6
   workup.ADDITIONwas added
7. 7
   ДругоеA white solid precipitated

Методика

A mixture of 70.23 g (0.344 mole) of 2-chloroethylphenylsulfone, 41.92 g (0.343 mole) of phenethylamine and 60 ml of triethylamine in 800 ml of acetonitrile was stirred at room temperature for 18 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol and excess of ethereal hydrogen chloride was added and ether was added. A white solid precipitated to give 68.39 g (60%) of white crystalline solid, m.p. 194°-196° C.

Источник