Реакция #4297

Уравнение реакции

2-chloroethylphenyl sulfone

methylamine

→

title compound

N-Methyl-2-(phenylsulfonyl)ethanamine

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ДругоеThe solvent is removed in vacuo
2. 2
   Другоеthe residue is partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   ЭкстракцияThe methylene chloride solution is extracted with dilute sulfuric acid
4. 4
   ЭкстракцияThe acidic extract
5. 5
   Экстракцияthe basic solution is extracted with methylene chloride
6. 6
   СушкаThe methylene chloride solution is dried over magnesium sulfate
7. 7
   Другоеthe solvent is removed in vacuo

Методика

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

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