Реакция #429504

Уравнение реакции

4-n-pentylcyclohexylmethanol

methanesulfonyl chloride

water

→

4-n-pentylcyclohexylmethyl methanesulfonate

Выход 99.2%

Растворители

pyridine

toluene

Условия реакции

Обработка

1. 1
   ДругоеAfter the reaction
2. 2
   Экстракцияsubjected to extraction with toluene
3. 3
   Промывкаby washing successively with 5%-hydrochloric acid aqueous solution and water
4. 4
   Сушкаdrying with anhydrous magnesium sulfate
5. 5
   ФильтрацияThe resultant organic layer was subjected to filtration

Методика

8.0 g of 4-n-pentylcyclohexylmethanol was dissolved in a mixture solvent of 8 ml of pyridine and 8 ml of toluene. To the solution, 6.0 g of methanesulfonyl chloride was added dropwise below 10° C., followed by stirring overnight at room temperature. After the reaction, the reaction mixture was poured into cold water and subjected to extraction with toluene, followed by washing successively with 5%-hydrochloric acid aqueous solution and water and drying with anhydrous magnesium sulfate. The resultant organic layer was subjected to filtration, followed by distilling-off of the solvent to obtain 11.3 g of 4-n-pentylcyclohexylmethyl methanesulfonate.

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