Реакция #429503

Уравнение реакции

aluminum lithium hydride

4-n-pentylcyclohexanecarbonyl chloride

hydrochloric acid

→

4-n-pentylcyclohexylmethanol

Выход 96.4%

Растворители

ether

ether

Условия реакции

Обработка

1. 1
   ДругоеAfter the reaction
2. 2
   Экстракцияwas subjected to extraction with ether
3. 3
   ПромывкаThe organic layer was washed successively with water, 5%-sodium hydroxide, and water
4. 4
   Сушкаby drying with anhydrous magnesium sulfate
5. 5
   ФильтрацияThe resultant organic layer was subjected to filtration

Методика

To a dispersion of 1.75 g of aluminum lithium hydride in 40 ml of dry ether, a solution of 10 g of 4-n-pentylcyclohexanecarbonyl chloride in 12 ml of ether was added dropwise below 5° C., followed by stirring overnight at room temperature. After the reaction, the reaction mixture was acidified with 5%-hydrochloric acid aqueous solution until a pH value of 1 were shown and was subjected to extraction with ether. The organic layer was washed successively with water, 5%-sodium hydroxide, and water, followed by drying with anhydrous magnesium sulfate. The resultant organic layer was subjected to filtration, followed by distilling-off of the solvent to obtain 8.2 g of 4-n-pentylcyclohexylmethanol.

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