Реакция #42896

ord-2052f34460534cc1876edc3ac9e2e20d

Уравнение реакции

COC(=O)c1cscc1NC(=O)C(F)Cl
4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester
Oc1ccc(Cl)c(Cl)c1
3,4-dichlorophenol
→
O=C(O)c1cscc1NC(=O)C(F)Oc1ccc(Cl)c(Cl)c1
title compound
O=C(O)c1cscc1NC(=O)C(F)Oc1ccc(Cl)c(Cl)c1
Rac-4-[2-(3,4-Dichloro-phenoxy)-2-fluoro-acetylamino]-thiophene-3-carboxylic acid

Реактанты

COC(=O)c1cscc1NC(=O)C(F)Cl
4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester
Oc1ccc(Cl)c(Cl)c1
3,4-dichlorophenol

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

In analogy to Example 58, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 3,4-dichlorophenol. MS (m/e): 362.0 (M−H).

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US07732452B2uspto-grants-2010_06