Реакция #428851

Уравнение реакции

sulfuric acid

3,6-dimethyl-oct-4-yne-3,6-diol

→

2,5-diethyl-2,5-di-methyldihydrofuran-3-one

Растворители

water

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture is maintained at 80° C. for 4 hours
2. 2
   Температураto cool to ambient temperature
3. 3
   ЭкстракцияThe mixture is extracted with diethyl ether (3×150 ml)
4. 4
   Промывкаwashed with water
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   ФильтрацияThe mixture is filtered
7. 7
   Другоеthe filtrate is evaporated under reduced pressure

Методика

A mixture of mercury (II) acetate (2.7 g, 0.0084 mol), sulfuric acid (2.7 ml, 0.027 mol), water (270 ml) and 3,6-dimethyl-oct-4-yne-3,6-diol (27.0 g, 0.159 mol) is heated at 80° C. The reaction mixture is maintained at 80° C. for 4 hours and allowed to cool to ambient temperature. The mixture is extracted with diethyl ether (3×150 ml), the organic phases are combined, washed with water, and dried over anhydrous sodium sulfate. The mixture is filtered and the filtrate is evaporated under reduced pressure to give 2,5-diethyl-2,5-di-methyldihydrofuran-3-one (20 g) as a colourless oil.

Источник